Eight published human clinical trials and multiple modes-of-action show that EpiCor has a wide range of real life health benefits. These studies show EpiCor supports a strong immune system and healthy gut to help people live more healthy days by:

  • Supporting year-round and seasonal respiratory and sinus health.*
  • Optimizing immune defenses to face daily challenges.*
  • Maintaining healthy gut function.*

Proven Immune Strength®1,2,3,4,5,6,7

EpiCor doesn’t just boost the immune system. It’s clinically shown to strengthen the immune system on four levels to better support your overall health and wellness.*

1) Increasing sIgA (secretory Immunoglobulin A) Antibodies1,4,5

sIgA is the primary antibody found in mucus, tears, saliva, mother’s milk and other areas8. When pathogens get into your skin, eyes, mouth and mucus membranes, sIgA helps trap them before they cause harm9. EpiCor strengthens this first line of defense by helping increase sIgA in saliva.* By increasing  sIgA, EpiCor helps your body protect itself from environmental challenges all year long.2,3*

2) Increasing White Blood Cell (Natural Killer Cell) Activity5

NK cells are white blood cells that are to be fast and effective in seeking out and destroying infected cells at the initial occurrence10. NK cells are called “natural killer” because they don’t need to be activated by other cells to differentiate “good” cells from “bad” cells11. This makes them quick to respond to keep your body healthy. EpiCor strengthens this second line of defense by helping increase Natural Killer (NK) cell activity in as little as two hours.* By increasing NK cell activity, EpiCor works rapidly to strengthen your immune system to help with daily challenges.*

3) Increasing Antioxidant Power5

Antioxidants circulate in your blood and tissues and help protect you from cellular oxidative damage, which may affect how your immune system works over time12.  EpiCor strengthens this third line of defense by increasing antioxidant power in as little as two hours.* By increasing antioxidant power, EpiCor works in your body to help protect your cells.*

4) Microbiome Booster™7

Around 70% of your immune system is in your gastrointestinal (GI) tract, which houses thousands of bacteria species. EpiCor strengthens this fourth level of defense by boosting beneficial bacteria levels.*

EpiCor acts as a Microbiome Booster by positively shifting the microbiome to help increase beneficial bacteria species and reduce harmful species. When it comes to immune health, EpiCor helps increase Anaerostipes, a genus containing butyrate-producing bacteria. Butyrate has been shown to support the innate immune system.*

EpiCor also increases good bacteria within the Bacteroidetes phylum and reduces unfavorable bacteria within the Firmicutes phylum. Studies have shown that a higher Firmicutes to Bacteroidetes ratio has been associated with constipation-related discomfort. EpiCor significantly increases the Bacteroides and Prevotella genera within the Bacteriodetes phylum. These genera are known to help accelerate the GI transit and may be a reason why EpiCor was shown to improve stool regularity.*

Finally, a Microbiome Booster should positively impact gut health. Published research shows that EpiCor also helps to significantly improve healthy gut function by reducing bloating, feelings of fullness and overall digestive discomfort in mildly constipated subjects.*


Infograph on A Strong, Healthy Immune System I Download PDF



  1. Jensen, G. S.; Patterson, K. M.; Barnes, J.; Schauss, A. G.; Beaman, R.; Reeves, S.; Robinson, L., A Double-Blind Placebo-Controlled, Randomized Pilot Study: Consumption of a High-Metabolite Immunogen from Yeast Culture has Beneficial Effects on Erythrocyte Health and Mucosal Immune Protection in Healthy Subjects. The Open Nutrition Journal 2008, 2, 68-75.
  2. Moyad, M. A.; Robinson, L. E.; Zawada, E. T., Jr.; Kittelsrud, J. M.; Chen, D. G.; Reeves, S. G.; Weaver, S. E., Effects of a modified yeast supplement on cold/flu symptoms. Urol Nurs 2008, 28 (1), 50-5. 
  3. Moyad, M. A.; Robinson, L. E.; Zawada, E. T.; Kittelsrud, J.; Chen, D. G.; Reeves, S. G.; Weaver, S., Immunogenic yeast-based fermentate for cold/flu-like symptoms in nonvaccinated individuals. J Altern Complement Med 2010, 16 (2), 213-8.
  4. Moyad, M. A.; Robinson, L. E.; Kittelsrud, J. M.; Reeves, S. G.; Weaver, S. E.; Guzman, A. I.; Bubak, M. E., Immunogenic yeast-based fermentation product reduces allergic rhinitis-induced nasal congestion: a randomized, double-blind, placebo-controlled trial. Adv Ther 2009, 26 (8), 795-804.
  5. Jensen, G. S.; Redman, K. A.; Benson, K. F.; Carter, S. G.; Mitzner, M. A.; Reeves, S.; Robinson, L., Antioxidant bioavailability and rapid immune-modulating effects after consumption of a single acute dose of a high-metabolite yeast immunogen: results of a placebo-controlled double-blinded crossover pilot study. J Med Food 2011, 14 (9), 1002-10.trial. 
  6. Jensen, G. S.; Carter, S. G.; Reeves, S. G.; Robinson, L. E.; Benson, K. F., Anti-Inflammatory Properties of a Dried Fermentate In Vitro and In Vivo. J Med Food 2014.
  7. Pinheiro, I.; Robinson, L.; Verhelst, A.; Marzorati, M.; Winkens, B.; den Abbeele, P. V.; Possemiers, S., A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial. BMC Complement Altern Med 2017, 17 (1), 441
  8. Delacroix DL et al..” IgA subclasses in various secretions and in serum,”  Immunology 1982 Oct;47(2):383–385
  9. Marcotte, H., Lavoie, M.C., “Oral Microbial Ecology and the Role of Salivary Immunoglobulin A,” Microbiology and Molecular Biology Reviews, 1998 March; 62(1): 71–109. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC98907/
  10. Pediatr., J., “Natural killer cells and immune surveillance,” Jornal de Pediatria, 2008 Aug; Vol. 84 no.4 suppl.0
  11. Vivier, E., Raulet, D.H., Moretta, A., Caligiuri, M.A., Zitvogel, L., Lanier, L.L., Yokoyama, W.M. & Ugolini, S.. "Innate or Adaptive Immunity? The Example of Natural Killer Cells". Science 2011; 331: 44–49. doi:10.1126/science.1198687
  12. Uttara, B., Singh, A.V., Zamboni, P., Mahajan, R. T., “Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options,” Current Neuropharmacology, 2009 March; 7(1): 65–74