Embria Health

Embria's High Standards in Developing Research*

Embria Health Sciences builds upon over 70 years of science and research into the technology supporting our ingredients. We’re committed to meeting or exceeding governmental and industry standards demonstrating safety and efficacy. Scientists know that not all research is created equal. Embria’s approach towards scientific studies on EpiCor involve:

  • Well-designed protocols to answer specific research questions and achieve accurate results
  • Healthy, non-stressed test subjects with ages ranging from 18-65 to show:
    • Benefits reflect the largest possible population segment
    • Results can be used by customers for legal structure/function claims
    • Broader health claims in other countries such as Canada
  • Measurement of clear clinical endpoints that:
    • Observe the impact of consumption in terms of improved maintenance of health status
    • Allow reproduction and validation
    • Produce statistically significant results
    • Experts recognize and use to access wellness
  • Publication in peer-reviewed, MEDLINE-listed journals
  • Examination of inter-connected relationships of immunity including:
    • Upper respiratory conditions (cold and flu symptoms)
    • Allergy symptoms
    • Inflammation
    • Gut Health
    • Biomarkers and modes of action

EpiCor’s many benefits can be easily formulated into diverse product lines. Companies have the ability to create differentiated products and make strong immune health claims supported by science.

Research supporting EpiCor: 

Seven published human clinical trials

Colds and flu Symptoms (vaccinated and nonvaccinated)

  • “Immunogenic yeast-based fermentate for cold/flu-like symptoms in nonvaccinated individuals,” The Journal of Alternative and Complementary Medicine, 2010

  • “Effects of a modified yeast supplement on cold/flu symptoms,” Urologic Nursing, 2008

Allergy Symptoms

  • “Immunogenic yeast-based fermentation product reduces allergic rhinitis-induced nasal congestion: a randomized, double-blind, placebo-controlled trial,” Advance in Therapy, 2009

Rapid response

  • “Antioxidant bioavailability and rapid immune-modulating effects after consumption of a single acute dose of a high-metabolite yeast immunogen: results of a placebo-controlled double-blinded crossover pilot study,” Journal of Medicinal Food, 2011

Digestive Health & Microbiome

  • "A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial," BMC Complementary and Alternative Medicine, 2017

Immune strength through measuring sIgA (PDF)

  • “A double-blind placebo-controlled, randomized pilot study: consumption of a high-metabolite immunogen from yeast culture has beneficial effects on erythrocyte health and mucosal immune protection in healthy subjects,” The Open Nutrition Journal, 2008

Immune balance and strength through measuring sIgE & sIgA (PDF)

  • “A double-blind placebo-controlled, randomized pilot study: consumption of a high-metabolite immunogen from yeast culture has beneficial effects on erythrocyte health and mucosal immune protection in healthy subjects,” The Open Nutrition Journal, 2008

Published animal studies

Inflammation Prevention/Reduction Mode

  •  “A dried yeast fermentate prevents and reduces inflammation in two separate experimental immune Models,” Evidence-Based Complementary and Alternative Medicine, 2012

Inflammation Treatment Model

  • “A dried yeast fermentate prevents and reduces inflammation in two separate experimental immune Models,” Evidence-Based Complementary and Alternative Medicine, 2012

Published in vitro studies

  • Mode of Action

    • “An anti-inflammatory immunogen from yeast culture induces activation and alters chemokine receptor expression on human natural killer cells and B lymphocytes in vitro,” Nutrition Research, 2007

  • Gut Health

    • "A Dried Yeast Fermentate Selectively Modulates both the Luminal and Mucosal Gut Microbiota and Protects against Inflammation, As Studied in an Integrated in Vitro Approach," Journal of Agricultural and Food Chemistry, 2013

Published safety studies

  •   “A (2012) Safety Evaluation of a Proprietary Food-Grade, Dried Fermentate Preparation of Saccharomyces cerevisiae,” International Journal of Toxicology, 2012

Download Articles

Human Clinical Trials

Summary of Human Clinical Trials PDF

Cold and Flu Symptoms
“Immunogenic yeast-based fermentate for cold/flu-like symptoms in nonvaccinated individuals,” The Journal of Alternative and Complementary Medicine, 2010  |  Download

“Effects of a modified yeast supplement on cold/flu symptoms,” Urologic Nursing, 2008  |  Download

Allergy Symptoms
Summary PDF
“Immunogenic yeast-based fermentation product reduces allergic rhinitis-induced nasal congestion: a randomized, double-blind, placebo-controlled trial,” Advance in Therapy, 2009  |  Download

Rapid Response
Summary PDF
“Antioxidant bioavailability and rapid immune-modulating effects after consumption of a single acute dose of a high-metabolite yeast immunogen: results of a placebo-controlled double-blinded crossover pilot study,” Journal of Medicinal Food, 2011 |  Download

Immune strength through measuring sIgA & Immune balance and strength through measuring sIgE & sIgA
“A double-blind placebo-controlled, randomized pilot study: consumption of a high-metabolite immunogen from yeast culture has beneficial effects on erythrocyte health and mucosal immune protection in healthy subjects,” The Open Nutrition Journal, 2008  |  Download


Animal Studies

Summary PDF
“A dried yeast fermentate prevents and reduces inflammation in two separate experimental immune Models,” Evidence-Based Complementary and Alternative Medicine, 2012 | Download


In Vitro Studies

Mode of Action
"An anti-inflammatory immunogen from yeast culture induces activation and alters chemokine receptor expression on human natural killer cells and B lymphocytes in vitro," Nutrition Research, 2007 | Download

Gut Health
"A Dried Yeast Fermentate Selectively Modulates both the Luminal and Mucosal Gut Microbiota and Protects against Inflammation, As Studied in an Integrated in Vitro Approach," Journal of Agricultural and Food Chemistry, 2013  |  Download

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